Thời gian: 8 giờ ngày 25/11/2022

Tại: Phòng Chuyên đề

Magnetic Resonance to Study Bio-nano Interfaces

Tatyana I. Smirnova, Alex I. Smirnov

Department of Chemistry, North Carolina State University Raleigh, NC 27606, USA

Nanostructures continue to find many new applications in modern technologies and basic research. Some notable nanotechnologies include development nanocarriers for drug delivery, new nanoscale-based approaches for biosensing, including quantum sensing, and hybrid bio-nanomaterials that combine manmade nanostructures with self-assembly of biological macromolecules and their complexes. Further progress in these and other areas call for the methods capable of providing atomic scale data on the structural organization and dynamics of molecules in the interfacial layers. Particularly important are the measurements of the hydrophobic effect and electrostatic interactions - the major forces related to chemical reactivity and/or recognition properties of bionanomaterials. In this presentation we discuss how some of the current gaps in characterization of nano interfaces could be filled by magnetic resonance methods, such as solid state Nuclear Magnetic Resonance (NMR) and spin-labeling Electron Paramagnetic Resonance (EPR).  The latter method is particularly suited to study nanoparticle-liquid interface even at low concentrations. Specific applications will be illustrated by results of the ongoing EPR and NMR studies at NCSU of nanopore-confined lipid bilayer membranes formed by a self-assembly inside high density arrays of nanopores, interfacial electrostatic properties of silica nanoparticles functionalized with artificial cellular membranes, and spin properties of nanodiamonds employed for quantum sensing. 

Opportunities for graduate studies in these and other interdisciplinary areas at NCSU Chemistry will be also discussed.